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Peter Lavrentiev
Peter Lavrentiev

The Antidote: Inside The World O !!EXCLUSIVE!!

In recent years, a number of programmes around the world have shown that providing naloxone to people likely to witness an opioid overdose, in combination with training on the use of naloxone and on the resuscitation of people following an opioid overdose, could substantially reduce the number of deaths resulting from opioid overdose. This is particularly relevant for people with opioid use disorder and leaving prison, as they have very high rates of opioid overdose during the first four weeks after release.

The Antidote: Inside The World O


The gap between recommendations and practice is significant. Only half of countries provide access to effective treatment options for opioid dependence and less than 10% of people worldwide in need of such treatment are receiving it.(5)

Can education be the antidote to a world prone to fracture along environmental, social, and economic fault lines? Can education systems incorporate new insights into how children learn, cultivate scientific thinking, and become more inclusive of people pushed to the margins?

In considering these questions, it is important to note that investments in education have a delayed effect. Children entering school today will be fully functioning adults only 15-20 years from now. To shape the world of 2050, we need to act now.

ComEngage is a strategy and insights technology platform that allows you to continuously engage with a representative sample of your community members providing an environment to get reliable and valid information to respond to current issues in your quickly changing world.

With little or no effort, we recognize the ugly effects of greed and selfishness on our society, culture, and nations. The greed of others makes this world a less pleasurable place to live for all of us. We wish they would change for the sake of everyone. In some cases, we even unify and protest to pressure them to change.

Jeffery Houghton, management professor, had studied how college students coped with stress through adaptive (i.e. exercise, meditation, social networking) and maladaptive (i.e. binge drinking, substance abuse, negative thoughts) behaviors before the world was dramatically altered by COVID-19 in early 2020.

Now leap ahead to early 2011: the grinding recovery from the worst financial crisis in eighty years, the raging political storm over Obamacare, a drumbeat of lurid press reports about the drug business, revealing an industry in crisis and under siege. Vertex, after twenty-two years and $3.6 billion in losses, was about to launch its first drug under its own name, a major breakthrough against the leading cause of advanced liver disease. It had a second drug nearing regulatory approval that promised to revolutionize the treatment of the most common inherited fatal disease in the United States and Europe. Just as the world around it was shuddering, Vertex was poised to soar. What better vantage point for witnessing the mounting collision of medicine, money, and society?

To gain more insight into the history of Vertex Pharmaceuticals and learn what it truly takes to create a winning business in the fiercely competitive biotech industry,'s health-care bureau chief Max Macaluso spoke with Barry Werth, an award-winning journalist who has followed Vertex almost from the day it opened its doors. Werth's book The Billion-Dollar Molecule, widely regarded as a must-read for passionate biotech investors, offered an inside look at Vertex soon after it was established. Earlier this month, Werth released a sequel, The Antidote: Inside the World of New Pharma, which continues the Vertex story and chronicles the company's path from a fledgling start-up to a company with a multibillion-dollar market cap.

I think that what distinguished Vertex more than anything else at that time was the scope and breadth of its ambition. It was shooting to not just develop a new drug, or build a company based on some novel use of a new technology, but really to displace what everybody agreed was the world's best drug discovery company.

What furthers the allure of Afridi is that there is no secret to him. He is not deceiving batters through sleight of hand or mystery spin but by simply performing at a level that is higher than his opponents can handle. The dismissals of Sharma, Rahul and Finch were not deliveries that just beat them for pace, or just snuck past their inside edge, but balls that in that moment in time were devastatingly superior to what they could muster in reply. These are players who, without exaggeration, are likely to have literally hit one million balls in their lifetimes and yet were unable to get within three bat widths of this one from Shaheen.

Today, Shaheen Shah Afridi had bowled 21 balls of his allotted 24 and gone for just 17 runs. His next three went for 18 as Matthew Wade saw Australia to a dramatic victory with three consecutive sixes. Afridi was so close to glory and yet undeservedly ended up as the fall guy in a campaign he has dominated and provided countless memories from. Afridi may have ended up on the losing side today, but he will continue to be the antidote to many a world-class batter for years to come.

You are an investor with goals and desires for your financial life reaching far out into the future. Unfortunately, the journey to achieving your long-term wealth goals follows a road that is not always smooth, clear and free of debris. Sometimes the market and the world at large will litter our path with obstacles for us to overcome. Global markets have been experiencing increased volatility, which comes in stark contrast to the even, steady growth that we often expect.

Expanding beyond this period and looking at performance for each of the 11 decades starting in 1900 and ending in 2010, the US market outperformed the world market in five decades and underperformed in the other six.

For Trump and those who share his fear of a world slipping out of their grasp, the construction of walls will not fortify America, as they argue it will. No, these walls will do nothing but stifle, constrict, insulate and shrink our country.

They are telling us in no uncertain terms that our nation is no longer the international paragon of justice, morality and regard for human rights and the rule of law that we have claimed to be for generations. They are telling us that America has failed, and that we have failed the world.

For good and ill, information, ideas, truth and lies now move around the world at speeds and volumes that can scarcely be contained, even if those with the power to contain them were inclined to do so.

For Trump and those who share his fear of a world slipping out of their grasp, the construction of walls will not fortify America, as they argue it will. No, these walls will do nothing but stifle, constrict, insulate and shrink our country. To build a wall is to retreat while standing still.

As pharmaceutical firms set aside competitive interests and liberal democracies (other than ours) dispense with national rivalries, the free and almost instantaneous flow of information and communication is allowing the search for a life-saving cure to advance at an almost exponential rate. The agents of change in this world will not be hemmed in by walls.

In my experience, you just need to convince one person to take that leap, buy a headset (all of my friends have purchased the $299 Quest 2), and then razzle dazzle them with visits to some of the more undeniably thrilling worlds. Then, the rest of the dominoes will fall. I went from having just one friend with a headset to three friends with headsets to a gang of six virtual warriors. All of whom, I should add, are spread across the U.S. and none of whom are tech-savvy in the slightest.

Yes, the light finds its way through the cracks. We see this every single day. Yesterday, a couple from Ukraine entered our warehouse (pictured above). They were ballroom dance world champions back home, and now they own and run a Fred Astaire dance studio in Sleepy Hollow. They sponsored a fundraiser in their community and raised $8200. With family back home, and a frail mother in her 90s, tears and stories followed. I offered to give them a tour, to invite them to the light that was finding its way in. To be in it, with us.

The Many Worlds view, on the other hand, states that you end up branching out into an entirely new identity as you progress toward any definition of Enough. And once this separation happens, these worlds can no longer communicate with one another at all (similar to the quantum physics interpretation).

Keep this in mind as you progress through your Many Worlds of Enough. The world of Enough you occupy today is completely foreign to the one you occupied a decade ago, as it should be. But how did you arrive here? Was your trend primarily sculpted through external events like lifestyle shifts, pay changes, and new environments? How much course correction have you done after conducting an honest audit of your ambitions? Have you done this at all?


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